Site Activation Manager

Your focus will be on coordinating site start-up and activation delivery, resolving issues, and developing team capability.

Key responsibilities include:

• Build strong working relationships with investigative sites and support a positive sponsor-site experience throughout start-up.
• Collect, review, QC, and file essential documents required for submission and activation.
• Review and negotiate ICF changes with sites and stakeholders; manage translations, checklists, filing, and amendment updates as required.
• Ensure REB submissions are made and approval documentation is complete and activation-ready.
• Support regulatory and clinical trial start-up activities across the US and Canada, including coordination of submission, approval, and study activation workflows.
• Collaborate with sites and internal stakeholders to set and achieve Regulatory Greenlight (RGL) goals that support timely site activation.
• Escalate risks, manage timelines, and maintain accurate documentation and tracking in systems such as CTMS and the eTMF.

You will have solid site start-up and activation experience, with the ability to manage competing priorities and develop your team.

Required qualifications and experience:

• Clinical trial start-up experience in a site-facing or dedicated site role.
• Solid understanding of ICH GCP, applicable ethics committee requirements (IRB/REB), and regulatory submission processes across the United States and Canada.
• Fluency in English.
• Experience with essential document collection, QC, and filing.
• Experience with ICF review, negotiation, and amendment management.
• Strong cross-functional collaboration and stakeholder management skills within a sponsor-partner operating model involving ICON.

Employment with ICON is contingent upon having the legal right to work in the country where the role is based.

ICON offers a competitive and comprehensive total rewards package designed to support your health, wellbeing, and career development.

Benefits may include:

• Competitive base salary and performance related incentives
• Health and wellbeing programmes including medical, dental, and vision coverage where applicable
• Retirement and pension plans
• Life assurance and disability coverage
• Employee assistance programmes and wellbeing resources
• Learning and development opportunities through structured training and career pathways

Benefits may vary depending on role and location.

Visit our careers site to read more about the benefits ICON offers.