Postdoctoral Scientist - Mendell Lab

is seeking a driven and passionate Postdoctoral Associate to join our group. We are a diverse group of collaborative scientists investigating broad questions in RNA biology. In particular, we are interested in understanding how genes are regulated post-transcriptionally, how various classes of noncoding RNAs such as microRNAs, long noncoding RNAs, small nucleolar RNAs, and tRNAs participate in these regulatory pathways, and how these pathways go awry in human disease. We use a variety of approaches and model systems to address these questions including high-throughput screens, animal modeling, and mechanistic studies including structural biology. We are seeking additional laboratory members who share our passion for RNA biology and are enthusiastic to join our tight-knit team.

There are several available projects in the lab, and it is expected that postdoctoral associates will bring their own ideas and expertise to advance ongoing areas of research while developing an independent research program. Areas of research in the Mendell lab that we are excited about include:

• Identification of new functions for noncoding RNAs.

• Regulation of microRNA activity and impact on health and disease.

• Mechanistic and structural dissection of noncoding RNA functions.

• Post-transcriptional regulation of mRNA translation and stability.

Please learn more about our group at our lab website, follow us on X or Bluesky, and read our papers at the links below:

Lab website: https://labs.utsouthwestern.edu/mendell-lab X: @Mendell_lab Bluesky: @mendell-lab.bsky.social Publications: https://www.ncbi.nlm.nih.gov/myncbi/joshua.mendell.1/bibliography/public/

as part of your application:

• A cover letter including a summary of your research experience, your career goals, and your expertise in the relevant field(s).

• Your curriculum vitae including a list of publications with brief (2-3 sentences) descriptions of your contributions to the published work.

• Names and contact information for at least 3 references.

• Opportunity to work in an exciting, cutting-edge, and supportive research environment.

• Broad training in biochemistry, molecular biology, genetics, high-throughput methodologies, and animal modeling.

• Training in scientific writing and communication.

• Mentorship tailored to your scientific and professional goals.

• The opportunity to mentor junior colleagues and work collaboratively as part of a team.

• Opportunities for professional and educational development and growth, including assistance with preparing postdoctoral fellowships, job applications, and interviews.

• The opportunity to present original work at scientific meetings.

• Access to world-class core facilities for animal modeling, structural biology, high throughput sequencing and screening, metabolomics, and many more.

• Access to the vibrant and collaborative research environment at UT Southwestern.

• A competitive compensation package, with comprehensive health and welfare benefits.

• Develop independent research projects based on your interests, expertise, and goals, including the opportunity to establish a research program that will form the basis for your own independent research laboratory upon completion of postdoctoral training.

• Write scientific manuscripts describing research findings.

• Attend national and international meetings to present research findings, learn about the latest advances in the field, and develop a scientific network.

• Apply for fellowships and grants.

• Mentor junior scientists.

• Ph.D. degree in a scientific discipline such as biochemistry, molecular biology, genetics, structural biology, developmental biology, or cancer biology.

• Less than two years of prior postdoctoral research experience.

• Resilient and positive approach to scientific research.

• Willingness to fully participate in lab and departmental activities, to positively engage with other team members and promote their success (e.g., by reviewing manuscripts, participating in practice talks), mentor junior colleagues, and contribute to an inclusive and productive research environment.

• Strong commitment to research integrity.