Thesis Work, 45/60 Credits - Targeted intestinal advanced drug delivery development

Are you passionate about drug delivery and interested in advancing targeted delivery technologies for inflammatory bowel disease? Join our team in Gothenburg and investigate how mesoporous silica nanoparticles could enhance drug delivery to inflamed colonic tissue. About AstraZeneca: AstraZeneca is a global, science-led, patient-centred biopharmaceutical company focusing on discovering, developing, and commercialising prescription medicines for some of the world's most serious diseases. But we're more than a global leading pharmaceutical company. At AstraZeneca, we're dedicated to being a Great Place to Work and empowering employees to push the boundaries of science and fuel their entrepreneurial spirit. About the Opportunity: As a Thesis Worker at AstraZeneca, you'll find an environment that's full of unique opportunities and exciting challenges. Here, you'll have the opportunity to pursue your areas of interest whilst equally developing a broad skillset and knowledge base to get the best out of your experience. You'll be working on meaningful projects to make an impact and deliver real value for our patients and our business. Thesis work description: Inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis, is a chronic condition with increasing incidence worldwide. Current treatments often require lifelong administration and may be associated with adverse effects, steroid dependence, and limited efficacy. In addition, the complex biology of IBD and the variability in treatment response create significant challenges in developing effective therapies for all patients. Advanced drug delivery systems that enable targeted and controlled release of therapeutic agents at diseased tissues could support more effective and precise treatment strategies. In this project, you will investigate the use of mesoporous silica nanoparticles (MSNs) to enhance drug delivery to inflamed colonic tissue, with the overall aim of developing a targeted oral drug delivery system for the local treatment of IBD. We are looking for a motivated master's thesis student to join a drug delivery project within AstraZeneca's Small Molecule Product Discovery and Development, Pharmaceutical Sciences organisation in Gothenburg. The project is part of an industrial PhD collaboration with the Department of Pharmacy at Uppsala University. The project will be primarily laboratory-based and will focus on in vitro studies. You will produce mesoporous silica nanoparticles using a sol-gel method and investigate their suitability for drug delivery. The work will include nanoparticle characterisation, drug loading, and evaluation of drug release using relevant in vitro assays. You will also analyse and interpret experimental data in the context of developing precision treatments for inflammatory bowel disease.

. In the event that we identify suitable candidates ahead of the scheduled closing date, we reserve the right to withdraw the vacancy earlier than published.

14-okt.-2026

04-nov.-2026 Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion, starting with our recruitment process. We welcome and consider applications from all qualified candidates, regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations, please complete the section in the application form.