Sr Scientist I - Biopharmaceutics

AbbVie's MPDD organization is seeking a highly motivated, talented, and creative scientist with expertise and experience in biopharmaceutics, pharmaceutical science, and drug delivery for a Senior Scientist I position. The primary role of this position is to serve as a biopharm project leader within MPDD to support discovery and early clinical programs and lead peptide oral delivery programs. This individual will lead CMC developability assessment for emerging molecules on peptide and small molecule pipeline programs. This role will also entail contributing towards developing our drug delivery capabilities with a focus on complex chemically synthesized modalities. This person will be working collaboratively with discovery and development partners across disciplines to improve delivery of these modalities and advance molecules to clinical development with improved developability profiles. The desired candidate will have a strong background and hand-on experience in the areas of physicochemical and/or biophysical properties and their impact on developability, preclinical and/or clinical formulation, biopharmaceutics, and drug delivery concepts relevant to small molecules and peptides

Qualifications

• Senior Scientist I typically requires Bachelors, Masters, or Ph.D. with 10+ (B.S.), 8+ (M.S.), and 1-3 (Ph.D.) years of experience in pharmaceutical or related industry. Preferred educational backgrounds include but are not restricted to Pharmaceutical Sciences, Pharmaceutical Engineering, Chemical/ Biomedical Engineering, and Materials Science.
• Fundamental understanding of biopharmaceutics as it relates to drug absorption across routes of administration including biorelevant dissolution testing, ex vivo permeability assessment, and peptide aggregation.
• Familiarity and preferred hands-on experience in physicochemical property assessment related to understanding CMC developability profile and potential risk mitigation strategies. Techniques of interest include, but are not limited to: chromatography, DSF, rat intestinal perfusion, Ussing Chambers, Franz Diffusion cells, X-ray diffraction, thermal analysis, microscopy, biophysical characterization techniques, etc.
• Experience developing and characterizing drug delivery systems to improve the bioperformance of peptides, in particular the use of permeation enhancer formulations.
• Experience supporting GLP toxicology studies for oral peptide development.
• Knowledge of preclinical and clinical formulation development principles relevant to chemically synthesized molecules across routes of administration.
• Excellent self-management and organizational skills.
• Demonstrated strong communication skills and ability to clearly communicate theories and concepts, influence others without authority, and drive technical excellence.

Additional Information

​Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law: ​

• The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location, and we may ultimately pay more or less than the posted range. This range may be modified in the future. ​
• We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.​
• This job is eligible to participate in our short-term incentive programs. ​

Note: No amount of pay is considered to be wages or compensation until such amount is earned, vested, and determinable. The amount and availability of any bonus, commission, incentive, benefits, or any other form of compensation and benefits that are allocable to a particular employee remains in the Company's sole and absolute discretion unless and until paid and may be modified at the Company's sole and absolute discretion, consistent with applicable law. ​

AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community.  Equal Opportunity Employer/Veterans/Disabled. US & Puerto Rico only - to learn more, visit https://www.abbvie.com/join-us/equal-employment-opportunity-employer.html US & Puerto Rico applicants seeking a reasonable accommodation, click here to learn more: https://www.abbvie.com/join-us/reasonable-accommodations.html