Senior/Executive Director, Reverse Translation, Oncology Translational Research

• Lead independent studies on high-priority mechanistic questions that cut across the TA, with the mandate and resources to pursue them.
• Prioritize across three question types: disease-focused/cross-MOA, MOA-focused/cross-disease, and shelved programs mined for learnings that inform live assets.
• Develop findings into next-generation hypotheses and combination strategies that feed pipeline growth with Discovery.
• Take in and prioritize active mechanistic questions from the disease-area TR leads across all solid and heme indications.
• Lead laboratory-based research to address why programs work, why they fail, and how resistance develops - returning usable answers on a defined clock.
• Design and test combination strategies that potentiate benefit and break resistance.
• Build and run the lab; consolidate DAS-program scientists under one leader, and structure resources to support deep expertise on the different key anticancer MOAs.
• Own the platform - omics, functional/perturbation biology, and in vitro/in vivo and organoid models - for mechanistic characterization of drugs and TR samples.
• There may be opportunity to grow the team strategically as the mandate expands.
• Serve as a member of the Core SLT for Translational Research, contributing to org-wide scientific strategy and priorities.
• Serve as the scientific link between reverse translation and Discovery, with scope jointly defined with Discovery leadership; may be heavily involved in early-development and Discovery governance meetings.
• Align closely with Medical Affairs and Commercial to connect mechanistic insight to lifecycle and portfolio priorities.
• Drive mechanism-driven, TR-led publications, including the Mechanism Series.
• Mentor scientists and build a culture of rigor and candid scientific debate.
• Measure the group by impact on program and portfolio decisions, not activity.

• PhD, MD, or MD/PhD in cancer biology, molecular biology, immunology, pharmacology, or related.
• 10+ years (Sr Director) / 12+ years (Exec Director) in oncology discovery or translational research, including hands-on lab leadership.
• Broad MOA/MOR expertise and a track record turning clinical observations into testable lab hypotheses.
• Built and led wet-lab teams and run omics and functional-characterization platforms.
• Effective at the Discovery-TR interface in a matrix, across multiple disease areas.
• Strong publication record (first/last author) and clear scientific communication.

• Command of multiomics, perturbation biology, organoid models, and computational data integration.
• Experience mining shelved programs for portfolio-relevant learnings.
• Track record designing combination and resistance-reversal strategies across modalities.
• Experience partnering with Medical Affairs and Commercial on lifecycle-relevant science.

Subject to the terms of their respective plans, employees are eligible to participate in the Company's consolidated retirement plan (pension) and savings plan (401(k)).

This position is eligible to participate in the Company's long-term incentive program.

Subject to the terms of their respective policies and date of hire, employees are eligible for the following time off benefits:

• Vacation -120 hours per calendar year
• Sick time - 40 hours per calendar year; for employees who reside in the State of Colorado -48 hours per calendar year; for employees who reside in the State of Washington -56 hours per calendar year
• Holiday pay, including Floating Holidays -13 days per calendar year
• Work, Personal and Family Time - up to 40 hours per calendar year
• Parental Leave - 480 hours within one year of the birth/adoption/foster care of a child
• Bereavement Leave - 240 hours for an immediate family member: 40 hours for an extended family member per calendar year
• Caregiver Leave - 80 hours in a 52-week rolling period10 days
• Volunteer Leave - 32 hours per calendar year
• Military Spouse Time-Off - 80 hours per calendar year

For additional general information on Company benefits, please go to: - https://www.careers.jnj.com/employee-benefits

Johnson & Johnson is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, disability, protected veteran status or other characteristics protected by federal, state or local law. We actively seek qualified candidates who are protected veterans and individuals with disabilities as defined under VEVRAA and Section 503 of the Rehabilitation Act.

Johnson & Johnson is committed to providing an interview process that is inclusive of our applicants' needs. If you are an individual with a disability and would like to request an accommodation, external applicants please contact us via https://www.jnj.com/contact-us/careers , internal employees contact AskGS to be directed to your accommodation resource.

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