Scientist – Disease Biology Discovery Research

Let's do this. Let's change the world. In this vital role you will commit to developing a deep understanding of disease biology, identify novel drug targets in the non-oncology space, and play a pivotal role in advancing our pre-clinical pipeline.

This position is within the Cardiometabolic Disorders Department of Amgen Research in South San Francisco. You will join a team of dedicated scientists committed to finding treatments for a diverse set of disease indications, including but not limited to cardiac, cardiovascular, fibrotic, and renal diseases.

To be successful in this role, you will need to have great molecular and cell biology laboratory skills, deep scientific curiosity, and strong interpersonal and communication skills to thrive in a collaborative environment. This is a permanent role that offers opportunities for advancement and career development.

If you have a passion for science and want to be part of an organization discovering new medicines that will impact patients' lives, we invite you to join us!

Key Responsibilities:

• Work collaboratively with a team of experts to generate robust data to support the preclinical validation of novel therapeutic targets and to advance the understanding of disease biology.

• Independently design and execute in vitro and ex vivo mechanism-of-action experiments, including troubleshooting, assay optimization, and data collection, analysis, and interpretation.

• Present research findings effectively in both written and oral formats for internal teams and external collaborators.

• Participating in cross-functional drug development teams as a key intellectual and technical contributor

Doctorate degree PhD

OR

Master's degree and 2 years of Molecular and Cell Biology experience

OR

Bachelor's degree and 4 years of Molecular and Cell Biology experience

Preferred Qualifications:

• Extensive experience in cell-based, molecular and biochemical techniques, including RNA isolation/qPCR, protein immunoprecipitation, immunoblotting, ELISA, flow cytometry, and cell imaging and image processing.

• Extensive experience in performing in vitro and cellular assays to dissect the function of genes of interest or the mechanism of action of therapeutic molecules as demonstrated by high-impact publications.

• Strong interpersonal and organizational skills, a high level of accuracy, commitment to record keeping, and attention to details.
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• Expertise with cell line engineering technologies, including CRISPR and virus-based stable cell line generation is preferred

• Demonstrated experience analyzing and interpreting complex datasets.

• Expertise with human iPSCs, especially iPSC-derived cardiomyocytes, is preferred

As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we'll support your journey every step of the way.

The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.

In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include:

• A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts
• A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
• Stock-based long-term incentives
• Award-winning time-off plans
• Flexible work models where possible. Refer to the Work Location Type in the job posting to see if this applies.