Principal Scientist – Inflammation Human Data & Computational Biology

Let’s do this. Let’s change the world. In this vital role you will combine experimental and computational strategies to accelerate discovery and development of innovative therapies. You will bring deep expertise across wet-lab biology and AI/ML-driven computational and agentic research approaches, enabling human-data-driven understanding of disease mechanisms and therapeutic opportunities.

Key Responsibilities

• Continuously apply computational, agentic and other AI-driven approaches to generate mechanistic insights, refine therapeutic hypotheses, and guide experimental design.

• Design, execute, analyze, and interpret studies to investigate disease mechanisms and test therapeutic hypotheses.

• Generate high-quality experimental data to support target identification, validation, and progression of Inflammation research programs.

• Integrate experimental findings with published literature, human genetics, clinical observations, and other data sources to develop mechanistic insights and inform scientific decision-making.

• Participate in scientific discussions, target reviews, and portfolio evaluations by contributing data-driven insights and recommendations.

• Present scientific findings and recommendations to project teams, governance forums, and departmental meetings.

• Maintain accurate documentation and contribute to organizational knowledge-sharing efforts.

• Embrace and contribute to a culture of scientific curiosity, collaboration, continuous learning, and operational excellence.

• Experience working effectively within highly collaborative and matrixed research environments.

• Ability to balance scientific rigor with urgency and adaptability in a dynamic research environment.

• Demonstrated commitment to teamwork, knowledge sharing, and continuous improvement.

As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we’ll support your journey every step of the way.

The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.

In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include:

• A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts

• A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan

• Stock-based long-term incentives

• Award-winning time-off plans

• Flexible work models where possible. Refer to the Work Location Type in the job posting to see if this applies.

Apply now and make a lasting impact with the Amgen team.