Analytical Project Senior Scientist Pharmaceutical Development

• MSc or PhD or equivalent experience in a relevant scientific subject area (Analytical Chemistry, Pharmaceutical Sciences, Biochemistry, Biotechnology or related).
• Experience of analytical development work and CMC deliveries across projects.
• Experience working in GMP environments and corresponding instrument/equipment maintenance procedures.
• Practical experience with data and workflow tools used in analytical development (e.g., ELN/CDS, statistical software such as JMP/Minitab, and basic scripting in Python/R for data wrangling, visualization, and predictive model deployment).
• Strong proficiency with chromatographic techniques (HPLC/UPLC; LC-MS), dissolution and/or aerosol characterization techniques used for inhaled product (such as impactor analysis) and complementary methodologies for small and/or large molecules.
• Experience in method development (including use of supporting software), validation, transfer and lifecycle management under ICH guidelines and phase appropriate frameworks.
• Experience evaluating stability data and assigning shelf life to drug products.
• Experience authoring CMC analytical content and responding to regulatory queries across clinical development.
• Demonstrated business and digital acumen, including:
• Comfort working with data-rich environments and using digital tools to enhance scientific insight and decision-making.
• The ability to engage with emerging AI-enabled, automation, or advanced analytics approaches and translate them into practical, compliant applications within analytical development.
• A curious approach towards new technologies, with the judgement to balance innovation, scientific rigor, and regulatory expectations.
• Proficiency in English, oral and written.
• Excellent communication, stakeholder management and influencing skills

• Demonstrated ability to troubleshoot technical challenges and drive data driven decisions.
• Experience of advanced structured problem-solving techniques e.g. six sigma
• Fundamental digital and data capability relevant to analytical development, including proficiency with multivariate experimental design and basic DoE concepts for method and process understanding; working knowledge of statistics for analytical science (e.g., regression, ANOVA, capability/variation analysis, stability trending, OOS/OOT investigation).
• Experience with statistical analysis tools (e.g., Minitab) and DoE for method development, data evaluation and acceptance criteria.
• Experience applying advanced predictive analytics beyond foundational skills (e.g., Bayesian optimisation for robustness tuning, chemometrics for pattern recognition, mechanistic/hybrid models for dissolution or degradation kinetics, advanced statistical methods for specification setting and uncertainty quantification).
• For inhalation: advanced performance assessment techniques and aerosol characterisation; for oral products: solid-state characterisation (e.g., XRPD, DSC, TGA) and dissolution strategy.
• Experience supporting clinical manufacture and working with CMOs, including method transfer and comparability.
• Experience of leading teams and/or scientific projects within a global organization and with external partners.
• Experience acting as project lead/skill lead and influencing cross functional strategies.

At AstraZeneca, we're dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science and unleash your entrepreneurial spirit. There's no better place to make a difference to medicine, patients and society. An inclusive culture that champions diversity and collaboration, and always committed to lifelong learning, growth and development. We're on an exciting journey to pioneer the future of healthcare.

We welcome your application no later than