Senior Manager, Portfolio Analytics & Strategy

• Lead and facilitate the enterprise PTRS assessment process with Product Teams and cross-functional experts at key development, investment, and governance milestones.
• Own and continuously evolve the PTRS methodology, standards, benchmarks, guardrails, governance cadence, and documentation, including integration with portfolio and business-case processes.
• Oversee development of new PTRS and risk-assessment tools with the Technology organization and functional experts, including data products, evidence workflows, dashboards, and decision-support capabilities.

• Partner with Product Teams to assess risk across alternative target product profiles, indication and population choices, biomarker strategies, and clinical development options.
• Facilitate evidence-based discussions that distinguish established evidence from key assumptions, clarify what would confirm, challenge, or disconfirm the current risk posture, and help teams articulate trade-offs across risk, value, timing, cost, and resource demand.

• Support portfolio reviews, prioritization, and investment decisions by assessing portfolio-level trade-offs across risk, value, timing, cost, and resources and developing clear options for Governance and senior leaders.
• Lead cross-functional portfolio performance tracking and industry benchmark participation across cycle times, success rates, portfolio composition, productivity, throughput, and other development KPIs to identify trends, gaps, and improvement opportunities.

• Deliver decision-ready insights on portfolio risk, value, performance, and key trade-offs for Product Teams, Governance, and senior leadership. Maintain consistency across PTRS, valuation, planning, and governance assumptions, and use historical outcomes, internal performance trends, and external benchmarks to calibrate assessments and improve decision quality over time.

• Advanced degree in business, life sciences, medicine, statistics, decision sciences, or a related field preferred.

• 5+ years of experience in R&D portfolio management, portfolio analytics, life sciences or management consulting, or leading decision analysis initiatives.

• Working knowledge of decision analysis methodologies and probabilistic modeling techniques (e.g., decision trees, Monte Carlo simulation, risk modeling).

• Experience facilitating PTRS, probability of success (PoS), or comparable development risk assessments with cross-functional subject matter experts.

• Deep understanding of the end-to-end drug development process and the scientific, clinical, regulatory, CMC, operational, and competitive factors that influence program risk and probability of success.

• Comfort using AI-enabled tools and analytical capabilities to synthesize evidence, assess risk, develop insights, and improve decision support; experience applying these tools in an R&D, portfolio, or strategy setting.

• Strong analytical and strategic thinking skills, with the ability to synthesize complex information into clear, actionable insights.

• Executive presence and exceptional communication skills, with the ability to influence and engage senior leaders in both formal presentations and ad hoc discussions.

• Demonstrated ability to thrive in a fast-paced, ambiguous, and highly matrixed environment

As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we’ll support your journey every step of the way.

The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications. In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include:

• A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts
• A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
• Stock-based long-term incentives
• Award-winning time-off plans
• Flexible work models where possible. Refer to the Work Location Type in the job posting to see if this applies.